TiffToPDF can directly convert tiff into PDF.

Supports virtually all TIFF compressions, including ZIP,LZW,CCITT G4/G3, JPEG, Packbits. Outstanding compression. Can combine multiple directories and tiff into one PDF file. Does NOT need Adobe Acrobat software . Supports Multi-page tiff file to PDF conversion . set automatic despeckling (of B/W images; removes noise; clear spot) and skew-correction . When batch converting, several image files can be merged to create a single PDF file, or each image file may be converted into individual PDF files. Makes use of effective compression processing to minimize space occupied by the created PDF files. Password protection for PDF files with 40 or 128 bit encryption. Set file permissions to restrict printing, copying, and future modifications to the document. Specify any resolution in the generated PDF file. Optimized to increase speed. Set the document title, subject, author and keywords . Append to existing PDFs. Specify page size. Use Base 13 fonts and system fonts. Convert Text to PDF. Add bookmarks. Images can be from memory or disk. Set viewer preferences. Handle millions of pages. Page orientation. Arbitrary placement of images onto new PDF pages.